Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide …
The present study demonstrates that tempol inhibits superoxide anion-induced molecular and behavioral alterations, indicating that tempol deserves further preclinical studies as a promising analgesic and anti-inflammatory molecule for the treatment of inflammatory pain.
Tempol differently affects cellular redox changes and antioxidant ...
Jul 21, 2021 · Tempol at 1 mM inhibited the growth of lung cancer and normal cells by about 50% at 48 h but also significantly induced cell death, as evidenced by annexin V-positive cells.
Tempol, a Superoxide Dismutase Mimetic Agent, Ameliorates
Oct 1, 2014 · In the present study, the protective role of tempol, a membrane-permeable superoxide dismutase mimetic agent, was evaluated on mitochondrial dysfunction and the subsequent damage induced by cisplatin nephrotoxicity in mice.
Superoxide–lowering therapy with TEMPOL reverses arterial …
Short-term treatment of excessive superoxide with TEMPOL ameliorates large elastic artery stiffening and endothelial dysfunction with aging, and this is associated with normalization of arterial collagen I, eNOS, oxidative stress and inflammation. Keywords: superoxide dismutase, inflammation, collagen, nitric oxide, glycation endproducts.
Tempol, a membrane-permeable radical scavenger, reduces oxidant …
Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. The generation of reactive oxygen species (ROS) contributes to the pathogenesis of renal ischemia-reperfusion injury.
Tempol, a superoxide dismutase mimetic agent, ameliorates …
Oct 1, 2014 · In the present study, the protective role of tempol, a membrane-permeable superoxide dismutase mimetic agent, was evaluated on mitochondrial dysfunction and the subsequent damage induced by cisplatin nephrotoxicity in mice.
Tempol (4‐hydroxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl) is a potential redox agent in cells. The present study investigated changes in cellular reactive oxygen species (ROS) and glutathione (GSH)...
Tempol | C9H18NO2 | CID 137994 - PubChem
TEMPOL/PNA is more effective against depression of activity level by 6-OHDA than the non-recycling antioxidant, TEMPOL, in a murine model of catecholaminergic oxidative damage. TEMPOL/PNA is also less toxic than TEMPOL in mice, allowing administration of …
Tempol, a membrane-permeable radical scavenger, ameliorates ...
Aug 1, 2011 · Tempol is a stable, water-soluble, metal-independent SOD mimetic that has been widely used in models of oxidant-induced injury (Salvemini et al., 2002). In the present investigation, we are testing the role of superoxide anion in LPS-induced acute lung injury.
Superoxide‐lowering therapy with TEMPOL reverses arterial …
Dec 13, 2011 · Short‐term treatment of excessive superoxide with TEMPOL ameliorates large elastic artery stiffening and endothelial dysfunction with aging, and this is associated with normalization of arterial collagen I, eNOS, oxidative stress, and inflammation.
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