Targeting Chemokine Receptor CXCR4 and Translocator Protein …
Jul 12, 2018 · Weiberg D, Thackeray JT, Daum G, Sohns JM, Kropf S, Wester HJet al. Clinical molecular imaging of chemokine receptor CXCR4 expression in atherosclerotic plaque using 68Ga-pentixafor PET: correlation with cardiovascular risk factors and calcified plaque burden.
Atherosclerosis immunoimaging by positron emission …
In this review, we summarize the growing body of work focused on PET imaging of the immune system in atherosclerosis, highlighting its value as a tool in anti-atherosclerosis drug development, and to diagnose and guide therapeutic interventions.
Identification of key pathways and core genes involved in ...
In this study, we identified common differentially expressed genes (DEGs) in early and advanced plaques (GSE28829), and in stable and ruptured plaques (GSE41571), and used bioinformatics methods to determine the key pathways and core genes involved in …
Imaging Inflammation in Atherosclerosis with CXCR4-Directed
May 1, 2020 · Thackeray JT, Daum G, et al. Clinical molecular imaging of chemokine receptor CXCR4 expression in atherosclerotic plaque using 68 Ga-pentixafor PET: correlation with cardiovascular risk factors and calcified plaque burden. J Nucl Med. 2018; 59: 266 – 272.
Imaging the Cytokine Receptor CXCR4 in ... - Research Square
C-X-C motif chemokine receptor 4 (CXCR4) plays a prominent role in inflammation, atherosclerosis, and cancer biology. Therefore, CXCR4 represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis and arterial wall injury.
CXCR4-Directed Imaging in Solid Tumors - PMC
With the goal of expanding the application of CXCR4 theranostics to solid tumors, we aimed to elucidate the feasibility of CXCR4-targeted imaging in a variety of such neoplasms.
Chemokine Receptors: Key for Molecular Imaging of Inflammation …
Weiberg D, Thackeray JT, Daum G, Sohns JM, Kropf S, Wester HJ, et al. Clinical Molecular Imaging of Chemokine Receptor CXCR4 Expression in Atherosclerotic Plaque using (68)Ga-Pentixafor PET: Correlation with Cardiovascular Risk Factors and Calcified Plaque Burden.
Molecular imaging of arterial fibroblast activation protein ...
May 6, 2023 · Eur J Nucl Med Mol Imaging. 2023; 50 (10): 3011–3021. We aimed to assess prevalence, distribution, and intensity of in-vivo arterial wall fibroblast activation protein (FAP) uptake, and its association with calcified plaque burden, cardiovascular risk factors (CVRFs), and FAP-avid tumor burden.
Exploring Vessel Wall Biology In Vivo by Ultrasensitive Total-Body …
Ultrasensitive, high-resolution, extended-field-of-view total-body (TB) PET using the first-of-its-kind 194-cm axial-field-of-view uEXPLORER may facilitate the interrogation of biologic hallmarks of hitherto difficult-to-evaluate low-signal vessel wall pathology in cardiovascular disease.
Feasibility of In Vivo Imaging of Fibroblast Activation Protein in ...
Jun 1, 2022 · In this study, we aimed to quantify the arterial fibroblast activation via 68 Ga-conjugated quinoline-based FAP inhibitor (68 Ga-FAPI-04) PET/CT imaging in correlation with cardiovascular risk factors.