Adenine nucleotide translocator - Wikipedia
Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane.
The transport mechanism of the mitochondrial ADP/ATP carrier
Oct 1, 2016 · Rotation of three domains around a single translocation pathway is a unique mechanism. The mitochondrial ADP/ATP carrier imports ADP from the cytosol and exports ATP from the mitochondrial matrix, which are key transport steps for oxidative phosphorylation in eukaryotic organisms.
Membrane potential stimulates ADP import and ATP export by …
Nov 1, 2024 · The ping-pong kinetic mechanism of the mitochondrial ADP/ATP carrier stipulates that ADP 3− (three negative charges) is imported against the membrane potential and ATP 4− (four negative charges) is exported with the membrane potential.
The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier
Mitochondrial ADP/ATP carriers transport ADP into the mitochondrial matrix for ATP synthesis, and ATP out to fuel the cell, by cycling between cytoplasmic-open and matrix-open states.
H + transport is an integral function of the mitochondrial ADP/ATP carrier
Jul 24, 2019 · The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular production...
Substrate binding in the mitochondrial ADP/ATP carrier is a
Jun 23, 2022 · The mitochondrial ADP/ATP carriers have unique features that enable them to achieve a high flux of ADP and ATP across the mitochondrial inner membrane to sustain our daily activities.
Structure, substrate binding, and symmetry of the mitochondrial ADP/ATP ...
At both ends of oxidative phosphorylation, the mitochondrial ADP/ATP carrier (AAC) switches between two conformational states, the cytoplasmic and matrix states, to import and export nucleotides across the mitochondrial inner membrane.
H+ Transport is an Integral Function of the Mitochondrial ADP/ATP Carrier
The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular ATP production. In addition, AAC may mediate mitochondrial uncoupling, but this AAC function and its mechanisms remain elusive.
Structure of mitochondrial ADP/ATP carrier in complex with ...
Nov 6, 2003 · ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in the...
ATP-Binding Cassette and Solute Carrier Transporters ... - MDPI
Nov 27, 2024 · The ATP-binding cassette (ABC) and solute carrier (SLC) transporters play pivotal roles in cellular transport mechanisms, influencing a wide range of physiological processes and impacting various medical conditions. Recent advancements in structural biology and computational modeling have provided significant insights into their function and regulation. This review provides an overview of the ...