IgA: Structure, Function, and Developability - PMC
This review will focus primarily on human IgA, and will explore structure and function relationships and the prospect for developing IgA-based therapeutic monoclonal antibodies (mAb).
Immunoglobulin A (IgA) - Structure, Properties, Subclasses, …
Jan 23, 2024 · Structure of Immunoglobulin A (IgA) Immunoglobulin A (IgA) comprises 5 to 15% of the serum immunoglobulins and has a half-life of 6 days. It has a molecular weight of 160 kDa and a basic four-chain monomeric structure (two L and two H) chain proteins.
3D Structures of IgA, IgM, and Components - PMC
In common with other immunoglobulins, the IgA monomer consists of two identical heavy chains and two identical light chains forming a Y-shape structure (Figure 1). Each chain extends a variable region from its N-terminal, followed by a constant region.
Immunoglobulin A (IgA)- Structure, Subclasses and Functions
Jun 25, 2022 · Structure of IgA. Immunoglobulin A (IgA) is present in the serum as a 170 kDa, four polypeptide (two L and two H) chain protein. Its H-chain type is alpha (α). IgA exists in serum in both monomeric and dimeric forms. Although it exists primarily in monomeric form, followed by dimeric, trimeric and some tetrameric forms are also present.
Structure and function relationships in IgA - Mucosal Immunology
Sep 21, 2011 · Here, we provide an overview of human IgA structure, describing the distinguishing features of the IgA1 and IgA2 subclasses and mapping the sites of interaction with host receptors...
Structure and Function of Immunoglobulins - PMC - PubMed …
There are five main classes of heavy chain C domains. Each class defines the IgM, IgG, IgA, IgD, and IgE isotypes. IgG can be split into four subclasses, IgG1, IgG2, IgG3, and IgG4, each with its own biologic properties; and IgA can similarly be split into IgA1 and IgA2.
IgA: Structure, Function, and Developability - PubMed
Dec 5, 2019 · Indeed, IgA is not just the most prevalent antibody class at mucosal sites, but is also present at significant concentrations in serum. The unique structural features of the IgA heavy chain allow IgA to polymerise, resulting in mainly dimeric forms, along with some higher polymers, in secretions.
Serum IgA derives from the bone marrow and is principally monomeric in form (Fig. 1.1). However, the IgA in secretions, termed secretory IgA (SIgA), is chiefly polymeric. These locally produced polymers are principally dimers (Fig. 1.1), with a small proportion of higher polymers such as trimers and tetramers. 1.2. The Structure of Monomeric ...
5 Types of Immunoglobulins: IgG, IgM, IgA, IgD, and IgE
Apr 4, 2022 · Antibodies can be classified into five different classes; IgG, IgM, IgA, IgD, and IgE. All the antibodies have the basic four-chain antibody structure, but they have different heavy chains. The differences in the immunoglobulins are more pronounced in the Fc regions of the antibody, which leads to the triggering of different effector functions.
Structure and function relationships in IgA - ScienceDirect
Nov 1, 2011 · Here, we provide an overview of human IgA structure, describing the distinguishing features of the IgA1 and IgA2 subclasses and mapping the sites of interaction with host receptors important for IgA's functional repertoire.
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