Mechanisms and Models in Heart Failure | Circulation Research
May 13, 2021 · Despite repeated attempts to develop a unifying hypothesis that explains the pathophysiology of heart failure with reduced ejection fraction (HFrEF), no single conceptual model has withstood the test of time.
Mechanisms and Models in Heart Failure | Circulation
May 31, 2005 · In the present review we will summarize recent advances in the field of heart failure, with a focus on the new therapeutic strategies that have been developed for treating systolic heart failure.
Pathophysiology of heart failure - Wikipedia
The main pathophysiology of heart failure is a reduction in the efficiency of the heart muscle, through damage or overloading.
CV Physiology | Pathophysiology of Heart Failure
Pathophysiology of Heart Failure. Cardiac dysfunction precipitates changes in vascular function, blood volume, and neurohumoral status. These changes serve as compensatory mechanisms to help maintain cardiac output (primarily by the Frank-Starling mechanism) and arterial blood pressure (by systemic vasoconstriction). However, these compensatory ...
The pathophysiology of heart failure - PubMed
Heart failure is a clinical syndrome that results when the heart is unable to provide sufficient blood flow to meet metabolic requirements or accommodate systemic venous return. This common condition affects over 5 million people in the United States at a cost of $10-38 billion per year.
Mechanisms and Models in Heart Failure | Circulation
Aug 31, 1999 · As shown, heart failure may be viewed as a progressive disorder that is initiated after an index event either damages the heart muscle, with a resultant loss of functioning cardiac myocytes, or alternatively disrupts the ability of the myocardium to generate force, thereby preventing the heart from contracting normally.
The pathophysiology of heart failure - ScienceDirect
Sep 1, 2012 · Heart failure results from injury to the myocardium from a variety of causes including ischemic heart disease, hypertension, and diabetes. Less common etiologies include cardiomyopathies, valvular disease, myocarditis, infections, systemic toxins, …