Retroviral vector-mediated gene transfer has been central to the development of gene therapy. Retroviruses have several distinct advantages over other vectors, especially when permanent gene transfer ...

Insertional mutagenesis as an adverse effect of retroviral gene therapy Gene therapy for SCID-X1: 5 of 20 children with leukemia correlated with upregulation of an oncogene due to nearby vector ...

Ironically, the latest technique for producing transgenic cattle is based on a retroviral vector strategy reminiscent of that employed two decades ago to produce the first genetically engineered ...

Cells were transduced with a GFP-containing retroviral vector for 3.5 days on Retronectin ... Sorrentino, B.P. & Nienhuis, A.W. The hematopoietic system as a target for gene therapy.