Pramlintide, exenatide, α-glucosidase inhibitors, and the glinides are not included in this algorithm, owing to their generally lower overall glucose-lowering effectiveness, limited clinical data ...

The glucose surge can also be inhibited by α-glucosidase inhibitors, although gastrointestinal complaints are common with this class. Thiazolidinediones (TZDs) achieve HbA1c reductions in the 0.5 ...

α-Glucosidase inhibitors 0.5 0.8 Weight neutral Frequent GI side effects, three times/day dosing, expensive Exenatide 0.5 1.0 Weight loss Injections, frequent GI side effects, expensive ...