A new publication from Genes & Diseases; DOI 10.1016/j.gendis.2024.101284 , discusses the effect of long-term administration of green tea catechins ...

Cardiac diastolic dysfunction (CDD), ultimately leading to heart failure ... In this study, 12-month-old female mice were ...

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a major health concern. Pathological stimuli and interactions between cardiac fibroblasts (CFs) and other cell types may lead to ...

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We followed distinct mouse models of major HFpEF comorbidities for 2.5 ... Hyperglycemia accelerated diastolic dysfunction and HFpEF onset associated with reduced arterial flow and left ventricular ...

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Twenty-four patients (60%) who were subsequently diagnosed with HFpEF did not have guideline-defined diastolic dysfunction. Robust discrimination for HFpEF was seen for left atrial emptying ...