Cardiac diastolic dysfunction (CDD), ultimately leading to heart failure ... In this study, 12-month-old female mice were ...

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a major health concern. Pathological stimuli and interactions between cardiac fibroblasts (CFs) and other cell types may lead to ...

A new publication from Genes & Diseases; DOI 10.1016/j.gendis.2024.101284 , discusses the effect of long-term administration of green tea catechins ...

To address this unmet clinical need, we have identified a mouse model of arthritis, K/BxN F1 progeny, which recapitulates the specific diastolic dysfunction of RA patients; this is the first mouse ...

Following 20 weeks of HFD+L-NAME feeding, mice displayed diastolic dysfunction with an increased E/E’ ratio was apparent by echocardiography. This was coupled with a trend towards decreasing ...

Furthermore, the effects of the EMPA on a mouse model of transverse aortic constriction (TAC ... novel therapeutic targets to protect the heart from stress-induced cardiac dysfunction. The study ...

CS is not only an isolated decrease in cardiac function but a rapidly progressing multiorgan dysfunction accompanied by severe ... In our case this clustering concerned mean, systolic and diastolic ...

Diastolic dysfunction increasingly is recognized as an important cause of congestive heart failure (CHF). In this study, Mayo Clinic researchers surveyed a random sample of 2042 adults (age ...

Diastolic heart failure is defined clinically when signs and symptoms of heart failure are present in the presence of preserved left ventricular systolic function (ejection fraction >45%).