Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

San Francisco 49ers defensive end Nick Bosa (hip/oblique) missed his second contest in a row due to hip and oblique injuries.

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

ProFootballTalk founder Mike Florio has an intriguing idea for a change of scenery for Kyle Shanahan. Appearing on “The Rich ...

The 49ers superstar made the statement in a lengthy caption on his Instagram fee after the team put him on injured reserve ...

BUFFALO, N.Y. (WKBW) — For the second time this season and the 14th time in his career, Buffalo Bills quarterback Josh Allen ...

ET on Sunday, the Chicago Bears play at the San Francisco 49ers.In their last outing, the 49ers lost 35-10 to the Buffalo ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Head coach Kyle Shanahan reflected on the team's performance against the Bills, previewed the upcoming Week 14 matchup ...

On Sunday night against the Buffalo Bills, star running back Christian McCaffrey suffered a knee injury that may cost him the ...