Trials evaluating the use of hypertonic saline solutions for resuscitation after traumatic injury have not shown an overall mortality benefit compared with isotonic fluid administration.

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Hypertonic saline refers to any saline solution with a concentration of sodium chloride (NaCl) higher than physiologic (0.9%). Commonly used preparations include 2%, 3%, 5%, 7%, and 23% NaCl.

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The volume retrieved is determined, diluted 1:5 with sterile balanced salt solution (BSS), and filter sterilised ... of serum), following which an equivalent volume of sterile normal saline is then ...