Endocannabinoids in the brain play a key role in food intake and energy use. Modulating the action of these molecules could ...

Since GLP-1-based therapy is a promising novel treatment of type 2 diabetes, the strategy to inhibit the enzyme has been explored. Several DPP-4 inhibitors are in clinical development; these are ...

Influencing their activity can control their rates of reaction. Different chemicals can influence enzyme activity. Inhibitors can be used to stop an enzyme from binding to its substrate.

Proton pump inhibitors (PPIs ... PPIs bind to a certain type of protein called an enzyme that is located within the parietal cells, which line your stomach. This enzyme is the hydrogen-potassium ...

a MAO-B = monoamine oxidase type B, MAO-A = monoamine oxidase ... dose of drug required to provide clinically relevant inhibition of enzyme activity (80%) (mg/kg).

The inhibitors target the EZH2 enzyme, whose activity in tumor cells is now recognized as a significant factor in many cancers. The study, published Dec. 5 in Cancer Cell, found that EZH2 ...

and inhibiting this enzyme has been found to benefit lymphoma patients even when they have non-mutant EZH2. An EZH2 inhibitor called tazemetostat was approved by the FDA in 2020 for use in ...

Angiotensin II type 1 and 2 receptors (AT 1 and AT 2) are implicated in the pathogenesis of MFS. Researchers have tested the efficacy of the angiotensin-converting-enzyme (ACE) inhibitor ...