Hamilton County is a county in the U.S. state of Indiana. The 2020 United States Census recorded a population of 347,467. The county seat is Noblesville. Hamilton County is part of the Indianapolis-Carmel-Anderson, IN Metropolitan Statistical Area. Since the beginning of the 21st century, Hamilton County has been the second most populous county in Cent…Hamilton County is a county in the U.S. state of Indiana. The 2020 United States Census recorded a population of 347,467. The county seat is Noblesville. Hamilton County is part of the Indianapolis-Carmel-Anderson, IN Metropolitan Statistical Area. Since the beginning of the 21st century, Hamilton County has been the second most populous county in Central Indiana.