Lucerne or Luzern is a city in central Switzerland, in the German-speaking portion of the country. Lucerne is the capital of the canton of Lucern…Lucerne or Luzern is a city in central Switzerland, in the German-speaking portion of the country. Lucerne is the capital of the canton of Lucerne and part of the district of the same name. With a population of approximately 82,000 people, Lucerne is the most populous city in Central Switzerland, and a nexus of economics, transport, culture, and media in the region. The city's urban area consists of 19 municipalities and towns with an overall population of about 220,000 people.