Clinton is a town in Worcester County, Massachusetts, United States. The population was 15,428 at the 2020 census. Clinton was first settled in 1654 as a part of Lancaster after the land was deeded by Sachem Sholan of the Nashaway in 1643. It was officially incorporated as a separate town on March 14, 1850, and named after the DeWitt Clinton Hotel in New Yo…Clinton is a town in Worcester County, Massachusetts, United States. The population was 15,428 at the 2020 census. Clinton was first settled in 1654 as a part of Lancaster after the land was deeded by Sachem Sholan of the Nashaway in 1643. It was officially incorporated as a separate town on March 14, 1850, and named after the DeWitt Clinton Hotel in New York, a favorite place of the town's founders, Erastus Brigham Bigelow and his brother Horatio.