TLR antagonists are being investigated for the treatment of inflammatory diseases. Examples here include the inhibition of TLR7 and TLR9 in systemic lupus erythematosus, inhibition of TLR4 in ...

Xi’an Xintong Medicine Research Co. Ltd. has described Toll-like receptor 8 (TLR8) agonists reported to be useful for the treatment of cancer.

The Army G-8 is the Army’s lead for matching available resources to the defense strategy and the Army plan. We accomplish this through participation in the Office of the Secretary of Defense ...

In a recent Perspective in Nature Immunology 1, Blander and Medzhitov explored the function of Toll-like receptor (TLR) signaling in controlling the maturation of phagosomes in macrophages and ...

Grippy tyre with a great lifespan and puncture resistance. Not the fastest rolling, but for winter training it’s a great ...

Practically speaking, anything below 1,000Hz is not highly recommended on modern equipment — mice that are 500Hz or below ...

In 2023, Vinuesa received the Lupus Insight Prize for the discovery that gain-of-function mutations in the gene that encodes the toll-like receptor 7 (TLR7) cause human lupus. 18 Her team identified a ...

However, the Mariners simply cannot stop trying. With arguably the best starting rotation in the sport, all it will take is ...

Objectives Sjögren’s disease (SD) is an autoimmune disease affecting the exocrine glands that is associated with autoantibodies against Ro60/SS-A, anti-Ro52/TRIM21, La/SS-B and others. We examined the ...

IND cleared by FDA and dosing in the Phase 1 clinical trial initiated, with data expected in the first half of 2025Sanofi ...

Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has ...