At an up-and-down 3-4, the reigning NFC champion San Francisco 49ers can’t be reliably counted on as a bona fide contender. That makes Brandon Aiyuk’s season-ending knee injury an outright disaster for a Bay Area constellation of football superstars still chasing an elusive Lombardi Trophy.

Aiyuk was working his way into a groove this season, but his performance in 2024 just hasn’t been great. In the end, he’ll end his season with just 25 catches for 374 yards and no touchdowns in seven games played,

The San Francisco 49ers and fantasy football managers won't have star wide receiver Brandon Aiyuk at their disposal anytime soon following his knee injury.