Wilson is a city in and the county seat of Wilson County, North Carolina, United States. It is the 23rd most populous city in North Carolina. Loc…Wilson is a city in and the county seat of Wilson County, North Carolina, United States. It is the 23rd most populous city in North Carolina. Located approximately 40 mi east of the capital city of Raleigh, it is served by the interchange of Interstate 95 and U.S. Route 264. Wilson had an estimated population of 49,459 in 2019, according to the U.S. Census Bureau, and is also an anchor city of the Rocky Mount-Wilson-Roanoke Rapids CSA, with a total population of 297,726 as of 2018.
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